Specific parasitism of purified vaginal epithelial cells by Trichomonas vaginalis
نویسندگان
چکیده
منابع مشابه
Role of pH on Adhesion of Trichomonas Vaginalis Isolated from Symptomatic & Asymptomatic Women to Vaginal Epithelial Cells in Vitro
Background: Vaginal epithelium is the most important site for initial contact of the parasite infection in humans. Objective: To investigate the effect of Lactobacillus acidophilus (LA) and pH on attachment of T. vaginalis isolated from symptomatic and asymptomatic patients to vaginal epithelial cells (VECs). Methods: Following 1-4 hrs contact of parasite with VECs, wet mounts were prepared and...
متن کاملMorphological studies of the cytotoxicity of Trichomonas vaginalis to normal human vaginal epithelial cells in vitro.
In vitro cultured monolayers of normal human vaginal epithelial cells were incubated with axenic cultures of Trichomonas vaginalis. Two strains freshly isolated from patients with trichomoniasis and one strain that had been maintained in axenic culture for several years were studied. Freshly isolated trichomonads showed amoeboid movements, adherence to epithelial cell surfaces, and were cytotox...
متن کاملCytopathogenic effect of Trichomonas vaginalis on human vaginal epithelial cells cultured in vitro.
In this study we established human vaginal epithelial cells (hVECs) in culture and evaluated their interaction with Trichomonas vaginalis parasites to complement previous studies using other cell types. Primary cultures of hVECs were established. Contaminating fibroblasts were separated from epithelial cells by differential trypsinization. Specific antibody staining revealed that over 92% of ce...
متن کاملDeep sequencing of Trichomonas vaginalis during the early infection of vaginal epithelial cells and amoeboid transition.
The human pathogen Trichomonas vaginalis has the largest protozoan genome known, potentially encoding approximately 60,000 proteins. To what degree these genes are expressed is not well known and only a few key transcription factors and promoter domains have been identified. To shed light on the expression capacity of the parasite and transcriptional regulation during phase transitions, we deep...
متن کاملTrichomonas vaginalis adherence mediates differential gene expression in human vaginal epithelial cells.
Trichomonas vaginalis, an ancient protist, colonizes the vaginal mucosa causing trichomonosis, a vaginitis that sometimes leads to severe health complications. Preparatory to colonization of the vagina is the adhesion to vaginal epithelial cells (VECs) by trichomonads. We hypothesized that VECs alter the gene expression to form a complex signalling cascade in response to trichomonal adherence. ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1988
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.56.10.2558-2562.1988